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Splitting Nodes and Linking Channels: A Method for Assembling Biocircuits from Stochastic Elementary Units

机译:拆分节点和链接通道:一种组装方法   随机基本单位的生物电路

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摘要

Akin to electric circuits, we construct biocircuits that are manipulated bycutting and assembling channels through which stochastic information flows.This diagrammatic manipulation allows us to create a method which constructsnetworks by joining building blocks selected so that (a) they cover only basicprocesses; (b) it is scalable to large networks; (c) the mean andvariance-covariance from the Pauli master equation form a closed system and;(d) given the initial probability distribution, no special boundary conditionsare necessary to solve the master equation. The method aims to help with bothdesigning new synthetic signalling pathways and quantifying naturally existingregulatory networks.
机译:类似于电路,我们构建通过切割和组装随机信息流经的通道来操纵的生物电路。这种图解操作使我们能够创建一种方法,该方法通过连接选定的构建基块来构建网络,从而(a)它们仅覆盖基本过程; (b)可扩展到大型网络; (c)Pauli主方程的均值和方差-协方差形成一个封闭系统;并且(d)给定初始概率分布,无需特殊的边界条件即可求解该主方程。该方法旨在帮助设计新的合成信号通路和量化自然存在的调节网络。

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